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  Serial synchrotron crystallography for time-resolved structural biology

Pearson, A. R., & Mehrabi, P. (2020). Serial synchrotron crystallography for time-resolved structural biology. Current Opinion in Structural Biology, 65, 168-174. doi:10.1016/j.sbi.2020.06.019.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-37A8-E Version Permalink: https://hdl.handle.net/21.11116/0000-0007-37A9-D
Genre: Journal Article

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1-s2.0-S0959440X20301184-main.pdf (Publisher version), 2MB
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2020
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© the Author(s). Published by Elsevier Ltd.
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https://dx.doi.org/10.1016/j.sbi.2020.06.019 (Publisher version)
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 Creators:
Pearson, A. R.1, Author
Mehrabi, P.2, Author           
Affiliations:
1Institute for Nanostructure and Solid State Physics, Hamburg Centre for Ultrafast Imaging, Universität Hamburg, CFEL, ou_persistent22              
2Miller Group, Atomically Resolved Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_1938288              

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 Abstract: The current state-of-the-art experiments in time-resolved structural biology are undoubtedly the recent extremely impressive results that are emerging from XFEL-based experiments. However, there is a large range of macromolecular systems where the biological interest is predominantly in the slower dynamics (μs–s), that produce well diffracting microcrystals, and for which synchrotron-based experiments are extremely well suited. The combination of microfocus X-ray beams and the development of a range of sample delivery platforms has now made routine millisecond time-resolved experiments at microfocus macromolecular crystallography beamlines a real possibility and is driving development of dedicated endstations for time-resolved serial synchrotron crystallography.

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Language(s): eng - English
 Dates: 2020-102020-12
 Publication Status: Issued
 Pages: 7
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 Table of Contents: -
 Rev. Type: Internal
 Identifiers: DOI: 10.1016/j.sbi.2020.06.019
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Title: Current Opinion in Structural Biology
  Other : Curr. Opin. Struct. Biol.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 65 Sequence Number: - Start / End Page: 168 - 174 Identifier: ISSN: 0959-440X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578067