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Abstract:
Metabolic and functional alterations inside the pgACC were assessed by simultaneous quantitative in-vivo 2D-JPRESS measurements of GABA, glutamate
and glutamine levels, fMRI measurements during emotional stimulation and subjective evaluation of the emotional state in healthy volunteers and patients
with major depressive disorder (MDD). An altered excitation/inhibition balance was found. Changed neurotransmitter concentrations specifically relate to
reduced deactivation, and altered subjective evaluation of emotional intensities and anhedonia scores in the patient group. In addition, a decreased activity of
glial enzymes that are mediating the Glu reuptake from the synaptic cleft as well as the transformation of glutamate into glutamine is hypothesized.
