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  Catalytic Enantioselective Retro‐Aldol Reactions: Kinetic Resolution of β‐Hydroxyketones with Aldolase Antibodies

Zhong, G., Shabat, D., List, B., Anderson, J., Sinha, S. C., Lerner, R. A., et al. (1998). Catalytic Enantioselective Retro‐Aldol Reactions: Kinetic Resolution of β‐Hydroxyketones with Aldolase Antibodies. Angewandte Chemie International Edition, 37(18), 2481-2484. doi:10.1002/(SICI)1521-3773(19981002)37:18<2481:AID-ANIE2481>3.0.CO;2-T.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-A4FB-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-60BF-6
Genre: Journal Article

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 Creators:
Zhong, Guofu1, Author
Shabat , Doron1, Author
List, Benjamin1, Author           
Anderson, James1, Author
Sinha, Subhash C.1, Author
Lerner, Richard A.1, Author
Barbas, Carlos F.1, Author
Affiliations:
1The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., ou_persistent22              

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Free keywords: Aldol reactions; Asymmetric synthesis; Catalytic antibodies; Enantiomeric resolution; Retro-aldol reactions
 Abstract: High enantiomeric enrichment after 50% conversion: Racemates of aldols can be resolved by the title reaction [Eq.(1)] by use of the aldolase antibody 38C2 or 33F12; the ee values of the unconverted aldols are greater than 95% in most cases. Since the antibodies also catalyze the aldol reaction–that is, the reverse reaction–it is possible to prepare both enantiomers using the same antibody catalysts.

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Language(s): eng - English
 Dates: 1997-04-241998-10-02
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/(SICI)1521-3773(19981002)37:18<2481::AID-ANIE2481>3.0.CO;2-T
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 37 (18) Sequence Number: - Start / End Page: 2481 - 2484 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851