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  Genome-wide association study identifies 48 common genetic variants associated with handedness

Cuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., et al. (2021). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5, 59-70. doi:10.1038/s41562-020-00956-y.

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Cuellar-Partida, Gabriel1, 2, Author
Tung, Joyce Y.2, Author
Eriksson, Nicholas2, Author
Albrecht, Eva3, Author
Aliev, Fazil4, 5, Author
Andreassen, Ole A.6, 7, Author
Barroso, Inês8, 9, Author
Beckmann, Jacques S.10, Author
Boks, Marco P.11, Author
Boomsma, Dorret I.12, 13, Author
Boyd, Heather A.14, Author
Breteler, Monique M. B.15, Author
Campbell, Harry16, Author
Chasman, Daniel I.17, 18, Author
Cherkas, Lynn F.19, Author
Davies, Gail16, Author
De Geus, Eco J. C.12, 13, Author
Deary, Ian J.16, Author
Deloukas, Panos20, Author
Dick, Danielle M.4, Author
Duffy, David L.21, AuthorEriksson, Johan G.22, 23, 24, 25, AuthorEsko, Tõnu26, 27, AuthorFeenstra, Bjarke14, AuthorGeller, Frank14, AuthorGieger, Christian3, 28, AuthorGiegling, Ina29, AuthorGordon, Scott D.21, AuthorHan, Jiali30, AuthorHansen, Thomas F.31, 32, AuthorHartmann, Annette M.29, AuthorHayward, Caroline16, AuthorHeikkilä, Kauko33, AuthorHicks, Andrew A.34, AuthorHirschhorn, Joel N.18, 27, 35, AuthorHottenga, Jouke-Jan12, 13, AuthorHuffman, Jennifer E.16, AuthorHwang, Liang-Dar1, AuthorIkram, Mohammad A.36, AuthorKaprio, Jaakko33, AuthorKemp, John P.1, 37, AuthorKhaw, Kay-Tee9, AuthorKlopp, Norman38, AuthorKonte, Bettina29, AuthorKutalik, Zoltan10, 39, AuthorLahti, Jari33, 40, AuthorLi, Xin30, AuthorLoos, Ruth J. F.9, 41, AuthorLuciano, Michelle16, AuthorMagnusson, Sigurdur H.42, AuthorMangino, Massimo19, AuthorMarques-Vidal, Pedro10, AuthorMartin, Nicholas G.21, AuthorMcArdle, Wendy L.37, AuthorMcCarthy, Mark I.43, 44, AuthorMedina-Gomez, Carolina36, AuthorMelbye, Mads14, 45, 46, AuthorMelville, Scott A.34, AuthorMetspalu, Andres26, AuthorMilani, Lili26, AuthorMooser, Vincent10, AuthorNelis, Mari26, AuthorNyholt, Dale R.21, 47, AuthorO'Connell, Kevin S.6, AuthorOphoff, Roel A.36, 48, AuthorPalmer, Cameron49, AuthorPalotie, Aarno33, AuthorPalviainen, Teemu33, AuthorPare, Guillaume50, AuthorPaternoster, Lavinia37, AuthorPeltonen, Leena12, AuthorPenninx, Brenda W. J. H.12, 13, AuthorPolasek, Ozren51, 52, AuthorPramstaller, Peter P.34, AuthorProkopenko, Inga53, 54, AuthorRaikkonen, Katri12, 13, AuthorRipatti, Samuli33, AuthorRivadeneira, Fernando36, AuthorRudan, Igor16, AuthorRujescu, Dan29, AuthorSmit, Johannes H.12, 13, AuthorSmith, George Davey37, AuthorSmoller, Jordan W.27, 55, AuthorSoranzo, Nicole8, AuthorSpector, Tim D.19, AuthorSt Pourcain, Beate37, 56, 57, Author           Starr, John M.16, AuthorStefánsson, Hreinn42, AuthorSteinberg, Stacy42, AuthorTeder-Laving, Maris26, AuthorThorleifsson, Gudmar42, AuthorStefansson, Kari42, AuthorTimpson, Nicholas J.37, AuthorUitterlinden, André G.36, AuthorVan Duijn, Cornelia M.36, AuthorVan Rooij, Frank J. A.36, AuthorVink, Jaqueline M.12, 58, AuthorVollenweider, Peter10, AuthorVuoksimaa, Eero33, AuthorWaeber, Gérard10, AuthorWareham, Nicholas J.9, AuthorWarrington, Nicole1, AuthorWaterworth, Dawn59, AuthorWerge, Thomas31, 45, 60, AuthorWichmann, H.-Erich3, AuthorWiden, Elisabeth33, AuthorWillemsen, Gonneke12, AuthorWright, Alan F.16, AuthorWright, Margaret J.1, AuthorXu, Mousheng18, AuthorZhao, Jing Hua9, AuthorKraft, Peter18, AuthorHinds, David A.2, AuthorLindgren, Cecilia M.43, AuthorMagi, Reedik26, AuthorNeale, Benjamin M.27, 55, AuthorEvans, David M.1, 37, AuthorMedland, Sarah E.1, 21, Author more..
Affiliations:
1University of Queensland, Woolloongabba, Australia, ou_persistent22              
223andMe, Inc, Sunnyvale, CA, USA, ou_persistent22              
3Helmholtz Zentrum München, München, Germany, ou_persistent22              
4Virginia Commonwealth University, Richmond, VA, USA, ou_persistent22              
5Karabuk University, Karabük, Turkey, ou_persistent22              
6University of Oslo, Oslo, Norway, ou_persistent22              
7Oslo University Hospital, Oslo, Norway, ou_persistent22              
8Wellcome Sanger Institute, Hinxton, UK, ou_persistent22              
9University of Cambridge, Cambridge, UK, ou_persistent22              
10University of Lausanne, Lausanne, Switzerland, ou_persistent22              
11University Utrecht, Utrecht, The Netherlands, ou_persistent22              
12Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, ou_persistent22              
13Amsterdam University Medical Centers, Amsterdam, The Netherlands, ou_persistent22              
14Statens Serum Institut, Copenhagen, Denmark, ou_persistent22              
15German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ou_persistent22              
16University of Edinburgh, Edinburgh, UK, ou_persistent22              
17Brigham and Women’s Hospital, Boston, MA, USA, ou_persistent22              
18Harvard Medical School, Boston, MA, USA, ou_persistent22              
19King's College London, London, UK, ou_persistent22              
20Queen Mary University of London, London, UK, ou_persistent22              
21QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
22Helsinki University Hospital, Helsinki, Finland, ou_persistent22              
23Folkhälsan Research Center, Helsinki, Finland, ou_persistent22              
24Agency for Science Technology and Research, Singapore, Singapore, ou_persistent22              
25National University of Singapore, Singapore, Singapore, ou_persistent22              
26University of Tartu, Tartu, Estonia, ou_persistent22              
27Broad Institute of MIT and Harvard, Cambridge, MA, USA, ou_persistent22              
28German Center for Diabetes Research (DZD), Neuherberg, Germany, ou_persistent22              
29Martin-Luther-University Halle-Wittenberg, Halle, Germany, ou_persistent22              
30Indiana University, Indianapolis, IN, USA, ou_persistent22              
31Mental Health Services of Copenhagen, Copenhagen, Denmark, ou_persistent22              
32Copenhagen University Hospital , Glostrup, Denmark, ou_persistent22              
33University of Helsinki, Helsinki, Finland, ou_persistent22              
34Eurac Research, Bolzano, Italy, ou_persistent22              
35Boston Children’s Hospital, Boston, MA, USA, ou_persistent22              
36Erasmus Medical Center, Rotterdam, The Netherlands, ou_persistent22              
37University of Bristol, Bristol, UK, ou_persistent22              
38Hannover Medical School, Hannover, Germany, ou_persistent22              
39Swiss Institute of Bioinformatics, Lausanne, Switzerland, ou_persistent22              
40University of Turku, Turku, Finland, ou_persistent22              
41Icahn School of Medicine at Mount Sinai, New York, NY, USA, ou_persistent22              
42deCODE Genetics, Reykjavik, Iceland, ou_persistent22              
43University of Oxford, Oxford, UK, ou_persistent22              
44Genentech, South San Francisco, CA, USA, ou_persistent22              
45University of Copenhagen, Copenhagen, Denmark, ou_persistent22              
46Stanford University School of Medicine, Stanford, CA, USA, ou_persistent22              
47Queensland University of Technology, Brisbane, Australia, ou_persistent22              
48University California Los Angeles, Los Angeles, CA, USA, ou_persistent22              
49Columbia University, New York, NY, USA, ou_persistent22              
50McMaster University, Hamilton, Canada, ou_persistent22              
51University of Split School of Medicine, Split, Croatia, ou_persistent22              
52Psychiatric Hospital Sveti Ivan, Zagreb, Croatia, ou_persistent22              
53University of Surrey, Guildford, UK, ou_persistent22              
54Imperial College London, London, UK, ou_persistent22              
55Massachusetts General Hospital, Boston, MA, USA, ou_persistent22              
56Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
57Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
58Radboud University Nijmegen, External Organizations, ou_3055479              
59GlaxoSmithKline, Collegeville, PA, USA, ou_persistent22              
60The Lundbeck Foundation’s IPSYCH Initiative, Copenhegen, Denmark, ou_persistent22              

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 Abstract: Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

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Language(s): eng - English
 Dates: 2020-092020-09-282021
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41562-020-00956-y
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Title: Nature Human Behaviour
Source Genre: Journal
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Publ. Info: London : Nature Research
Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 59 - 70 Identifier: ISSN: 2397-3374
CoNE: https://pure.mpg.de/cone/journals/resource/2397-3374