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model-based analysis/functional connectivity/resting state fMRI/mirror neuron system/mentalizing network/schizophrenia
Abstract:
Impairments of social cognition are well documented in patients with
schizophrenia (SCZ), but the neural basis remains poorly understood. In
light of evidence that suggests that the "mirror neuron system" (MNS)
and the "mentalizing network" (MENT) are key substrates of
intersubjectivity and joint action, it has been suggested that
dysfunction of these neural networks may underlie social difficulties in
SCZ patients. Additionally, MNS and MENT might be associated differently
with positive vs negative symptoms, given prior social cognitive and
symptom associations. We assessed resting state functional connectivity
(RSFC) in meta-analytically defined MNS and MENT networks in this
patient group. Magnetic resonance imaging (MRI) scans were obtained from
116 patients and 133 age-, gender- and movement-matched healthy controls
(HC) at 5 different MRI sites. Network connectivity was analyzed for
group differences and correlations with clinical symptoms. Results
demonstrated decreased connectivity within the MNS and also the MENT in
patients compared to controls. Notably, dysconnectivity of the MNS was
related to symptom severity, while no such relationship was observed for
the MENT. In sum, these findings demonstrate that differential patterns
of dysconnectivity exist in SCZ patients, which may contribute
differently to the interpersonal difficulties commonly observed in the
disorder.
