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  Differential Patterns of Dysconnectivity in Mirror Neuron and Mentalizing Networks in Schizophrenia

Schilbach, L., Derntl, B., Aleman, A., Caspers, S., Clos, M., Diederen, K. M. J., et al. (2016). Differential Patterns of Dysconnectivity in Mirror Neuron and Mentalizing Networks in Schizophrenia. SCHIZOPHRENIA BULLETIN, 42(5), 1135-1148. doi:10.1093/schbul/sbw015.

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 Creators:
Schilbach, Leonhard1, Author              
Derntl, Birgit2, Author
Aleman, Andre2, Author
Caspers, Svenja2, Author
Clos, Mareike2, Author
Diederen, Kelly M. J.2, Author
Gruber, Oliver2, Author
Kogler, Lydia2, Author
Liemburg, Edith J.2, Author
Sommer, Iris E.2, Author
Mueller, Veronika I.2, Author
Cieslik, Edna C.2, Author
Eickhoff, Simon B.2, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2external, ou_persistent22              

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Free keywords: model-based analysis/functional connectivity/resting state fMRI/mirror neuron system/mentalizing network/schizophrenia
 Abstract: Impairments of social cognition are well documented in patients with schizophrenia (SCZ), but the neural basis remains poorly understood. In light of evidence that suggests that the "mirror neuron system" (MNS) and the "mentalizing network" (MENT) are key substrates of intersubjectivity and joint action, it has been suggested that dysfunction of these neural networks may underlie social difficulties in SCZ patients. Additionally, MNS and MENT might be associated differently with positive vs negative symptoms, given prior social cognitive and symptom associations. We assessed resting state functional connectivity (RSFC) in meta-analytically defined MNS and MENT networks in this patient group. Magnetic resonance imaging (MRI) scans were obtained from 116 patients and 133 age-, gender- and movement-matched healthy controls (HC) at 5 different MRI sites. Network connectivity was analyzed for group differences and correlations with clinical symptoms. Results demonstrated decreased connectivity within the MNS and also the MENT in patients compared to controls. Notably, dysconnectivity of the MNS was related to symptom severity, while no such relationship was observed for the MENT. In sum, these findings demonstrate that differential patterns of dysconnectivity exist in SCZ patients, which may contribute differently to the interpersonal difficulties commonly observed in the disorder.

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Language(s): eng - English
 Dates: 2016-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000386209900010
DOI: 10.1093/schbul/sbw015
 Degree: -

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Project name : Human Brain Project
Grant ID : 604102
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)

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Title: SCHIZOPHRENIA BULLETIN
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 42 (5) Sequence Number: - Start / End Page: 1135 - 1148 Identifier: ISSN: 0586-7614