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Abstract:
Sleep is characterized by reduced muscle activity resulting in reduced movement and a typical posture compatible with
relaxed muscles. Prior to each molt,
C.elegans
larvae go through a phase of behavioral quiescence called Lethargus.
Lethargus has sleep-like properties, but a specific posture has not yet been described. Do
C.elegans
larvae relax their
muscles during sleep and do they assume a typical posture? We measured worm posture and body wall muscle activity
using calcium imaging across the sleep-wake-like cycle. We found that worms were less curved and had less muscle
activity during the sleep-like state. We conclude that during Lethargus, muscle activity is reduced, resulting in a relaxed
body posture typical for a sleep-like state.
