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  Diabetic endothelin B receptor–deficient rats develop severe hypertension and progressive renal failure

Pfab, T., Thöne-Reineke, C., Theilig, F., Lange, I., Witt, H., Maser-Gluth, C., et al. (2006). Diabetic endothelin B receptor–deficient rats develop severe hypertension and progressive renal failure. Journal of the American Society of Nephrology (Baltimore, MD), 17, 1082-1089. doi:10.1681/ASN.2005080833.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8450-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8451-8
Genre: Journal Article
Alternative Title : J Am Soc Nephrol

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 Creators:
Pfab, Thiemo, Author
Thöne-Reineke, Christa, Author
Theilig, Franziska, Author
Lange, Ines, Author
Witt, Henning1, Author
Maser-Gluth, Christiane, Author
Bader, Michael, Author
Stasch, Johannes-Peter, Author
Ruiz, Patricia1, Author
Bachmann, Sebastian, Author
Yanagisawa, Masashi, Author
Hocher, Berthold, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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 Abstract: The endothelin (ET) system has been implicated in the pathogenesis of diabetic nephropathy. The role of the ET-B receptor (ETBR) is still unclear. The effect of ETBR deficiency on the progression of diabetic nephropathy in a streptozotocin model was analyzed in four groups: (1) Homozygous ETBR-deficient (ETBRd) diabetic rats, (2) ETBRd rats, (3) diabetic controls, and (4) wild-type controls. BP and kidney function were measured for 10 wk, followed by biochemical and histologic analysis of the kidneys. The study demonstrates that ETBRd diabetic rats on a normal-sodium diet develop severe hypertension, albuminuria, and a mild reduction of creatinine clearance. The strong BP rise seems not to be caused by activation of the renin-angiotensin-aldosterone system or by suppression of the nitric oxide system. Elevated plasma ET-1, possibly reflecting a reduced ETBR-dependent clearance, seems to cause the severe hypertension via the ETA receptor. The results do not support the hypothesis that a reduction of ETBR activity inhibits the progression of diabetic nephropathy. The study demonstrates for the first time that the combination of diabetes and ETBR deficiency causes severe low-renin hypertension with progressive renal failure.

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Language(s): eng - English
 Dates: 2006-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 312524
DOI: 10.1681/ASN.2005080833
 Degree: -

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Title: Journal of the American Society of Nephrology (Baltimore, MD)
  Alternative Title : J Am Soc Nephrol
Source Genre: Journal
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Pages: - Volume / Issue: 17 Sequence Number: - Start / End Page: 1082 - 1089 Identifier: ISSN: 1046-6673