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Abstract:
By eigenspace analysis of the
Bloch-McConnell equation we found a general
signal equation for chemical exchange
saturation transfer imaging experiments. The
solution is easy extendable to the multi-pool
situation in vivo including a broad semisolid MT
pool.
Investigation of the theory leads to an
interesting and easy to employ result: effects in the
Z-spectrum add up reciprocally! Therefore,
difference image methods lead to a clean CEST
contrast if images are first inverted and then subtracted. This allowed for clean in-vivo CEST evaluation in the case of acute stroke.
