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  Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings

Rivolta, D., Heidegger, T., Scheller, B., Sauer, A., Schaum, M., Birkner, K., et al. (2015). Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings. Schizophrenia bulletin, 41(5), 1105-14. doi:10.1093/schbul/sbv051.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-2D87-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-2D88-3
Genre: Journal Article

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http://www.ncbi.nlm.nih.gov/pubmed/25987642 (Any fulltext)
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Rivolta, D.1, Author
Heidegger, T., Author
Scheller, B., Author
Sauer, A.1, Author
Schaum, M., Author
Birkner, K.1, Author
Singer, W.1, Author
Wibral, M., Author
Uhlhaas, P. J.1, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              

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 Abstract: Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in the pathophysiology of schizophrenia (ScZ). The current study tested the effects of ketamine, a dissociative anesthetic and NMDA-R antagonist, on resting-state activity recorded with magnetoencephalography (MEG) in healthy volunteers. In a single-blind cross-over design, each participant (n = 12) received, on 2 different sessions, a subanesthetic dose of S-ketamine (0.006 mg/Kg) and saline injection. MEG-data were analyzed at sensor- and source-level in the beta (13-30 Hz) and gamma (30-90 Hz) frequency ranges. In addition, connectivity analysis at source-level was performed using transfer entropy (TE). Ketamine increased gamma-power while beta-band activity was decreased. Specifically, elevated 30-90 Hz activity was pronounced in subcortical (thalamus and hippocampus) and cortical (frontal and temporal cortex) regions, whilst reductions in beta-band power were localized to the precuneus, cerebellum, anterior cingulate, temporal and visual cortex. TE analysis demonstrated increased information transfer in a thalamo-cortical network after ketamine administration. The findings are consistent with the pronounced dysregulation of high-frequency oscillations following the inhibition of NMDA-R in animal models of ScZ as well as with evidence from electroencephalogram-data in ScZ-patients and increased functional connectivity during early illness stages. Moreover, our data highlight the potential contribution of thalamo-cortical connectivity patterns towards ketamine-induced neuronal dysregulation, which may be relevant for the understanding of ScZ as a disorder of disinhibition of neural circuits.

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Language(s): eng - English
 Dates: 2015-05-20
 Publication Status: Issued
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 Identifiers: Other: 25987642
DOI: 10.1093/schbul/sbv051
ISSN: 1745-1701 (Electronic)0586-7614 (Linking)
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Title: Schizophrenia bulletin
Source Genre: Journal
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Pages: - Volume / Issue: 41 (5) Sequence Number: - Start / End Page: 1105 - 14 Identifier: -