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  Inhibition of the rat renal Na+/H+ exchanger by beta-adrenergic antagonists

Friedrich, T., & Burckhardt, G. (1991). Inhibition of the rat renal Na+/H+ exchanger by beta-adrenergic antagonists. Biochemical and Biophysical Research Communications, 175(1), 311-317. doi:10.1016/s0006-291x(05)81236-7.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-B120-C Version Permalink: https://hdl.handle.net/21.11116/0000-0007-B121-B
Genre: Journal Article

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 Creators:
Friedrich, Thomas1, Author
Burckhardt, Gerhard2, Author           
Affiliations:
1BASF-Ludwigshafen, Hauptlabor, 6700 Ludwigshafen, Germany, ou_persistent22              
2Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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 Abstract: The beta-adrenergic antagonists, alprenolol and propranolol, inhibit the N+/H+ exchanger in rat renal brush-border membrane vesicles. Half-maximal inhibition occurs at 86 microM alprenolol and 36 microM propranolol. Similar to amiloride and Na+, propranolol protects the N+/H+ exchanger from irreversible inhibition by the carboxyl group reagent, N,N'-dicyclohexyl-carbodiimide (DCCD). Protection is incomplete, depends on propranolol concentration, and reaches a maximum at 0.4 mM propranolol. With a comparable dose dependence, propranolol protects a 65 kDa band from labeling with [14C]DCCD. The data indicate that beta-adrenergic antagonists specifically interact with the proximal tubular Na+/H+ exchanger.

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Language(s): eng - English
 Dates: 1991-01-162005-05-051991-02-28
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/s0006-291x(05)81236-7
PMID: 1671814
 Degree: -

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Title: Biochemical and Biophysical Research Communications
  Other : Biochem. Biophys. Res. Commun.
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 175 (1) Sequence Number: - Start / End Page: 311 - 317 Identifier: ISSN: 0006-291X
CoNE: https://pure.mpg.de/cone/journals/resource/954922652205_1