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  ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

Flynn, K. C., Hellal, F., Neukirchen, D., Jacob, S., Tahirovic, S., Dupraz, S., et al. (2012). ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. NEURON, 76(6), 1091-1107. doi:10.1016/j.neuron.2012.09.038.

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Flynn, Kevin C.1, Autor
Hellal, Farida2, Autor           
Neukirchen, Dorothee2, Autor           
Jacob, Sonja1, Autor
Tahirovic, Sabina2, Autor           
Dupraz, Sebastian1, Autor
Stem, Sina1, Autor
Garvalov, Boyan K.2, Autor           
Gurniak, Christine1, Autor
Shaw, Alisa E.1, Autor
Meyn, Liane2, Autor           
Wedlich-Soeldner, Roland3, Autor           
Bamburg, James R.1, Autor
Small, J. Victor1, Autor
Witke, Walter1, Autor
Bradke, Frank2, Autor           
Affiliations:
1external, ou_persistent22              
2Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society, ou_1113553              
3Wedlich-Söldner, Roland / Cellular Dynamics and Cell Patterning, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565174              

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Schlagwörter: GROWTH CONE MOTILITY; NEURONAL POLARITY; DEPOLYMERIZING FACTOR; FILAMENT TURNOVER; IN-VIVO; COFILIN; DYNAMICS; CELLS; NEURITOGENESIS; ESTABLISHMENT
 Zusammenfassung: Neurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons are spherical cells but this symmetry is broken through the initial formation of neurites. This fundamental step is thought to rely on actin and microtubule dynamics. However, it is unclear which aspects of the complex actin behavior control neuritogenesis and which molecular mechanisms are involved. Here, we demonstrate that augmented actin retrograde flow and protrusion dynamics facilitate neurite formation. Our data indicate that a single family of actin regulatory proteins, ADF/Cofilin, provides the required control of actin retrograde flow and dynamics to form neurites. In particular, the F-actin severing activity of ADF/Cofilin organizes space for the protrusion and bundling of microtubules, the backbone of neurites. Our data reveal how ADF/Cofilin organizes the cytoskeleton to drive actin retrograde flow and thus break the spherical shape of neurons.

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Sprache(n): eng - English
 Datum: 2012-12-20
 Publikationsstatus: Erschienen
 Seiten: 17
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000313154800008
DOI: 10.1016/j.neuron.2012.09.038
 Art des Abschluß: -

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Titel: NEURON
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Seiten: - Band / Heft: 76 (6) Artikelnummer: - Start- / Endseite: 1091 - 1107 Identifikator: ISSN: 0896-6273