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  Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

Manczinger, M., Boross, G., Kemény, L., Müller, V., Lenz, T. L., Papp, B., et al. (2019). Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLoS Biology, 17(1): e3000131. Retrieved from https://doi.org/10.1371/journal.pbio.3000131.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-F74E-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-F74F-0
Genre: Journal Article

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journal.pbio.3000131.pdf (Publisher version), 2MB
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https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000131 (Publisher version)
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 Creators:
Manczinger, Máté, Author
Boross, Gábor, Author
Kemény, Lajos, Author
Müller, Viktor, Author
Lenz, Tobias L.1, 2, Author           
Papp, Balázs, Author
Pál, Csaba, Author
Affiliations:
1Emmy Noether Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              
2Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              

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 Abstract: Whereas specialist major histocompatibility complex (MHC) molecules initiate immune response against only relatively few pathogens, generalists provide protection against a broad range. Accordingly, this study shows that the geographical distribution of generalist MHC alleles in human populations reflects exposure to diverse infectious diseases.

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Language(s): eng - English
 Dates: 2018-08-072019-01-152019-01-312019-01
 Publication Status: Issued
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 Identifiers: URI: https://doi.org/10.1371/journal.pbio.3000131
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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 17 (1) Sequence Number: e3000131 Start / End Page: - Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170