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  Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

McGrath, J., Capon, D. J., Smith, D. H., Chen, E. Y., Seeburg, P. H., Goeddel, D. V., et al. (1983). Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature, 304, 501-506. doi:10.1038/304501a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-E7E0-E Version Permalink: https://hdl.handle.net/21.11116/0000-0000-E7E1-D
Genre: Journal Article

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Nature_304_1983_501.pdf (Any fulltext), 705KB
 
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https://www.nature.com/articles/304501a0.pdf (Any fulltext)
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 Creators:
McGrath, John, Author
Capon, Daniel J., Author
Smith, Douglas H., Author
Chen, Ellson Y., Author
Seeburg, Peter H.1, Author           
Goeddel, David V., Author
Levinson, Arthur D., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Analysis of the organization and nucleotide sequence of two human loci related to the transforming gene of Kirsten murine sarcoma virus establishes one as a functional gene and the other as a processed pseudogene. The two final coding exons of the functional gene seem to have arisen by duplication. Differentially spliced mRNAs incorporating one or other of the duplicated exons probably served as the intermediates by which the viral transforming gene and the pseudogene were generated. This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing.

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Language(s): eng - English
 Dates: 1983-05-261983-06-151983
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/304501a0
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 304 Sequence Number: - Start / End Page: 501 - 506 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238