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Abstract:
We generated transgenic mice bearing a tamoxifen-dependent Cre recombinase expressed under the control of the dopamine-beta-hydroxylase promoter. By crossing to the ROSA26 reporter mice we show that tamoxifen-induced Cre recombinase in adult mice specifically activates beta-galactosidase expression in differentiated noradrenergic neurons of the central and peripheral nervous system. Tamoxifen application in adult mice did not induce beta-galactosidase activity in parasympathetic neurons that transiently express DBH during development. Thus, this transgenic mouse line represents a valuable tool to study gene function in mature noradrenergic neurons by conditional inactivation. genesis 49:935941, 2011. (c) 2011 Wiley Periodicals, Inc.
