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  Epigenetic Mechanisms in Early Mammalian Development

Solter, D., Hiiragi, T., Evsikov, A. V., Moyer, J., De Vries, W. N., Peaston, A. E., et al. (2004). Epigenetic Mechanisms in Early Mammalian Development. Cold Spring Harbor Symposia on Quantative Biology, LXIX, 1-7.

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 Creators:
Solter, D.1, Author              
Hiiragi, T.1, Author              
Evsikov, A. V., Author
Moyer, J., Author
De Vries, W. N., Author
Peaston, A. E., Author
Knowles, B. B., Author
Affiliations:
1Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243650              

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 Abstract: In one sense, development of multicellular organisms begins well before fertilization because the molecules and controlling mechanisms that direct early development are put in place during oogeneisis. The informational content of a mammalian egg at fertilization is not only restricted to its DNA sequence, but also to various DNA and chromatin modifications, specific macromolecules (RNAs and proteins), and possibly the characteristic architecture of the cytoplasm and plasma membrane. These sources of stored, necessary information can be viewed as epigenetic controlling mechanisms (Fig. 1). In the ensuing text we will briefly touch on these subjects, delineating what is presently known about them and, more important, what still remains to be eclucidated. The literature on these subjects is vast and space restrictions prevent us from citing each relevant paper, for which we apologize.

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Language(s): eng - English
 Dates: 2004
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 216119
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Title: Cold Spring Harbor Symposia on Quantative Biology
Source Genre: Journal
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Pages: - Volume / Issue: LXIX Sequence Number: - Start / End Page: 1 - 7 Identifier: -