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  Developing a Rat Model of Brainstem Coma: Initial MRI and MRA Investigations of Basilar Artery Occlusion

Pais Roldán, P., Edlow, B., & Yu, X. (2016). Developing a Rat Model of Brainstem Coma: Initial MRI and MRA Investigations of Basilar Artery Occlusion. Poster presented at 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-7BB1-E Version Permalink: https://hdl.handle.net/21.11116/0000-0000-FB11-2
Genre: Poster

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Pais Roldán, P1, 2, Author           
Edlow, B, Author
Yu, X1, 2, Author           
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The ascending reticular activating system (ARAS) of the brainstem mediates arousal, which is an essential component of consciousness. In order to infarct the ARAS and induce an unarousable state in rats, we performed a two-point basilar artery (BA) occlusion. We used high resolution MRI to map the neuroanatomical distribution of the resulting brainstem infarction and MRA to map the penetrating branches of the BA. BA occlusion reproducibly caused medial-ventral brainstem infarction but did not create an unarousable state, suggesting that a larger region of ARAS infarction will be needed to create a rat model of brainstem coma.

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 Dates: 2016-05-09
 Publication Status: Issued
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 Identifiers: BibTex Citekey: PaisRoldanEY2016
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Title: 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016)
Place of Event: Singapore
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Title: 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1468 Start / End Page: - Identifier: -