English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Evaluation of dysphagia by novel real-time MRI.

Olthoff, A., Carstens, P. O., Zhang, S., von Fintel, E., Friede, T., Lotz, J., et al. (2016). Evaluation of dysphagia by novel real-time MRI. Neurology, 87(20), 2132-2138. doi:10.1212/WNL.0000000000003337.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Olthoff, A., Author
Carstens, P. O., Author
Zhang, S., Author
von Fintel, E., Author
Friede, T., Author
Lotz, J., Author
Frahm, J.1, Author           
Schmidt, J., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

Content

show
hide
Free keywords: -
 Abstract: OBJECTIVE: To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). METHODS: Using RT-MRI, FEES, and VF, an unselected cohort of 20 patients with IBM was studied as index disease with a uniform dysphagia. Symptoms of IBM and dysphagia were explored by standardized tools including Swallowing-Related Quality of Life Questionnaire (SWAL-QoL), IBM Functional Rating Scale, Patient-Reported Functional Assessment, and Medical Research Council Scale. RESULTS: Dysphagia was noted in 80% of the patients and SWAL-QoL was impaired in patients with IBM compared to published reference values of healthy elderly. Swallowing in a supine position during RT-MRI was well-tolerated by all patients. RT-MRI equally revealed dysphagia compared to VF and FEES and correlated well with the SWAL-QoL. Only RT-MRI allowed precise time measurements and identification of the respective tissue morphology. The pharyngeal transit times were 2-fold longer compared to published reference values and significantly correlated with morphologic abnormalities. CONCLUSIONS: RT-MRI is safe and equally capable as VF to identify the cause of dysphagia in IBM. Advantages of RT-MRI include visualization of soft tissue, more reliable timing analysis, and lack of X-ray exposure. RT-MRI may become a routine diagnostic tool for detailed assessment of the esophagus and other moving parts of the body, facilitating longitudinal evaluations in daily practice and clinical trials.

Details

show
hide
Language(s): eng - English
 Dates: 2016-10-212016-11-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1212/WNL.0000000000003337
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neurology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 87 (20) Sequence Number: - Start / End Page: 2132 - 2138 Identifier: -