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  Structural and functional insights into nucleocytoplasmic transport

Beck, M., & Medalia, O. (2008). Structural and functional insights into nucleocytoplasmic transport. Histology and Histopathology, 23(8), 1025-1033. doi:10.14670/HH-23.1025.

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 Creators:
Beck, Martin1, Author              
Medalia, Ohad2, Author
Affiliations:
1Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule, Zürich, Switzerland, ou_persistent22              
2External Organizations, ou_persistent22              

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Free keywords: Cryo-electron tomography, Nuclear pore complex structure, Nucleocytoplasmic transport, Nucleoporin
 Abstract: The cell nucleus is surrounded by a double membrane system, the nuclear envelope (NE), with the outer nuclear membrane being continuous with the endoplasmic reticulum. Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes, forming aqueous channels that allow free diffusion of small molecules but that also mediate the energy-dependent transport of large macromolecules. The NPC represents the largest known molecular complex and is composed of about 30 different proteins, termed nucleoporins (Nups). Here, we review recent studies that provide novel insight into the structural and functional organization of nucleocytoplasmic transport. In addition, prospects towards a high resolution model of the nuclear pore are discussed.

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Language(s): eng - English
 Dates: 2008-02-2020082008
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.14670/HH-23.1025
BibTex Citekey: beck_structural_2008
 Degree: -

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Title: Histology and Histopathology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 23 (8) Sequence Number: - Start / End Page: 1025 - 1033 Identifier: ISSN: 1699-5848