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  Disentangling the neural correlates of corticobasal syndrome and corticobasal degeneration with systematic and quantitative ALE meta-analyses

Albrecht, F., Bisenius, S., Schaack, R. M., Neumann, J., & Schroeter, M. L. (2017). Disentangling the neural correlates of corticobasal syndrome and corticobasal degeneration with systematic and quantitative ALE meta-analyses. npj Parkinson's Disease, 3:. doi:10.1038/s41531-017-0012-6.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002C-ECFC-7 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-BA82-8
資料種別: 学術論文

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Albrecht_2016.pdf
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作成者

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 作成者:
Albrecht, Franziska1, 著者           
Bisenius, Sandrine1, 著者           
Schaack, Rodrigo Morales1, 著者
Neumann, Jane1, 2, 著者           
Schroeter, Matthias L.1, 3, 著者           
所属:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 要旨: Corticobasal degeneration is a scarce neurodegenerative disease, which can only be confirmed by histopathological examination. Reported to be associated with various clinical syndromes, its classical clinical phenotype is corticobasal syndrome. Due to the rareness of corticobasal syndrome/corticobasal degeneration and low numbers of patients included in single studies, meta-analyses are particularly suited to disentangle features of the clinical syndrome and histopathology. Using PubMed, we identified 11 magnetic resonance imaging studies measuring atrophy in 22 independent cohorts with 200 patients contrasted to 318 healthy controls. The anatomic likelihood estimation method was applied to reveal affected brain regions across studies. Corticobasal syndrome was related to gray matter loss in the basal ganglia/thalamus, frontal, parietal, and temporal lobes. In corticobasal degeneration patients, atrophy in the thalamus, frontal, temporal, and occipital lobes were found. Finally, in a conjunction analysis, the bilateral thalamus, the bilateral posterior frontomedian cortex, posterior midcingulate cortex and premotor area/supplementary motor area, and the left posterior superior and middle frontal gyrus/precentral gyrus were identified as areas associated with both, corticobasal syndrome and corticobasal degeneration. Remarkably, atrophy in the premotor area/supplementary motor area and posterior midcingulate/frontomedian cortex seems to be specific for corticobasal syndrome/corticobasal degeneration, whereas atrophy in the thalamus and the left posterior superior and middle frontal gyrus/precentral gyrus are also associated with other neurodegenerative diseases according to anatomic likelihood estimation method meta-analyses. Our study creates a new conceptual framework to understand, and distinguish between clinical features (corticobasal syndrome) and histopathological findings (corticobasal degeneration) by powerful data-driven meta-analytic approaches. Furthermore, it proposes regional-specific atrophy as an imaging biomarker for diagnosis of corticobasal syndrome/corticobasal degeneration ante-mortem.

資料詳細

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言語: eng - English
 日付: 2016-12-092016-02-032017-01-182017-03-31
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41531-017-0012-6
PMID: 28649612
PMC: PMC5459811
その他: eCollection 2017
 学位: -

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Project information

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Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)
Project name : -
Grant ID : -
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : 01GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J Fox Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
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Funding program : -
Funding organization : European Union (EU)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony

出版物 1

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出版物名: npj Parkinson's Disease
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: London : Nature Publ. Group
ページ: - 巻号: 3 通巻号: 12 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2373-8057
CoNE: https://pure.mpg.de/cone/journals/resource/2373-8057