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  Neuroanatomical correlates of food addiction symptoms and body mass index in the general population

Beyer, F., Garcia-Garcia, I., Heinrich, M., Schroeter, M. L., Sacher, J., Luck, T., et al. (2019). Neuroanatomical correlates of food addiction symptoms and body mass index in the general population. Human Brain Mapping. doi:10.1002/hbm.24557.

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 Urheber:
Beyer, Frauke1, 2, Autor           
Garcia-Garcia, Isabel1, 3, Autor           
Heinrich, Matthias1, Autor
Schroeter, Matthias L.1, 4, Autor           
Sacher, Julia1, Autor           
Luck, Tobias5, Autor
Riedel-Heller, Steffi G.5, Autor
Stumvoll, Michael6, Autor
Villringer, Arno1, 4, Autor           
Witte, A. Veronica1, 2, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
6Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              

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Schlagwörter: Body mass index; Cohort studies; Eating; Food addiction; Gray matter; Neuroimaging; Obesity
 Zusammenfassung: The food addiction model suggests neurobiological similarities between substance-related and addictive disorders and obesity. While structural brain differences have been consistently reported in these conditions, little is known about the neuroanatomical correlates of food addiction. We therefore aimed to determine whether symptoms of food addiction related to body mass index (BMI), personality, and brain structure in a large population-based sample. Participants of the LIFE-Adult study (n = 625; 20–59 years old, 45% women) answered the Yale Food Addiction Scale (YFAS) and further personality measures, underwent anthropometric assessments and high-resolution 3T-neuroimaging. A higher YFAS symptom score correlated with higher BMI, eating behavior traits, neuroticism, and stress. Higher BMI predicted significantly lower thickness of (pre)frontal, temporal and occipital cortex and increased volume of left nucleus accumbens. In a whole-brain analysis, YFAS symptom score was not associated with significant differences in cortical thickness or subcortical gray matter volumes. A hypothesis-driven Bayes factor analysis suggested a small, additional contribution of YFAS symptom score to lower right lateral orbitofrontal cortex thickness over the effect of BMI. Our study indicates that symptoms of food addiction do not account for the major part of the structural brain differences associated with BMI in the general population. Yet, symptoms of food addiction might explain additional variance in orbitofrontal cortex, a hub area of the reward network. Longitudinal studies implementing both anatomical and functional MRI could further disentangle the neural mechanisms of addictive eating behaviors.

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Sprache(n): eng - English
 Datum: 2019-01-152018-10-152019-02-142019-02-28
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.24557
PMID: 30816616
Anderer: Epub ahead of print
 Art des Abschluß: -

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Projektname : -
Grant ID : -
Förderprogramm : European Social Fund
Förderorganisation : European Commission (EC)
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Förderprogramm : European Regional Development Fund
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Free State of Saxony
Projektname : -
Grant ID : 713‐241202
Förderprogramm : -
Förderorganisation : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Projektname : -
Grant ID : 14505/2470
Förderprogramm : -
Förderorganisation : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Projektname : Obesity mechanisms / SFb 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : -
Förderprogramm : Branco Weiss Fellowship - Society in Science
Förderorganisation : ETH Zurich
Projektname : -
Grant ID : 25034
Förderprogramm : NARSAD Young Investigator Award
Förderorganisation : Brain and Behavior Research Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686