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  Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings

Tittmann, M., Günther, T., Sacher, J., Himmerich, H., Villringer, A., Hegerl, U., et al. (2014). Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings. International Journal of Imaging Systems and Technology, 24(2), 149-160. doi:10.1002/ima.22089.

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Tittmann, Mandy1, Autor
Günther, Thomas1, Autor
Sacher, Julia2, 3, Autor           
Himmerich, Hubertus1, Autor
Villringer, Arno2, 3, Autor           
Hegerl, Ulrich1, Autor
Schönknecht, Peter1, Autor
Affiliations:
1Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: MRI; Depression in the elderly; Hippocampus; Amygdala; Prefrontal cortex; Morphometry; Volumetry
 Zusammenfassung: Early-onset (EOD) and late-onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed.

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Sprache(n): eng - English
 Datum: 2014-05-052014-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1002/ima.22089
 Art des Abschluß: -

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Titel: International Journal of Imaging Systems and Technology
  Andere : Int. J. Imaging Syst. Technol.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: New York : John Wiley & Sons
Seiten: - Band / Heft: 24 (2) Artikelnummer: - Start- / Endseite: 149 - 160 Identifikator: ISSN: 0899-9457
CoNE: https://pure.mpg.de/cone/journals/resource/954925561596