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  Topographically guided hierarchical mineralization

Deng, X., Hasan, A., Elsharkawy, S., Tejeda-Montes, E., Tarakina, N. V., Greco, G., et al. (2021). Topographically guided hierarchical mineralization. Materials Today Bio, 100119. doi:10.1016/j.mtbio.2021.100119.

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Genre: Journal Article

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 Creators:
Deng, Xinru, Author
Hasan, Abshar, Author
Elsharkawy, Sherif, Author
Tejeda-Montes, Esther, Author
Tarakina, Nadezda V.1, Author              
Greco, Gabriele, Author
Nikulina, Elizaveta, Author
Stormonth-Darling, John M., Author
Convery, Neil, Author
Rodriguez-Cabello, Jose Carlos, Author
Boyde, Alan, Author
Gadegaard, Nikolaj, Author
Pugno, Nicola M., Author
Al-Jawad, Maisoon, Author
Mata, Alvaro, Author
Affiliations:
1Nadezda V. Tarakina, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2522693              

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Free keywords: Fluorapatite, protein-based biomineralization; hierarchical mineralization; elastin-like recombinamer; bone; dental enamel; crystallization; surface topographies
 Abstract: Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains a major limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topographies to grow spatially-guided mineralized structures. We reveal how well-defined geometrical spaces defined within the organic matrix by the surface topographies can trigger subtle changes in single nanocrystal co-alignment, which are then translated to drastic changes in mineralization at the micro and macroscale. Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures. We foresee that the capacity to direct the anisotropic growth of such structures would offer important implications in the design of biomineralizing synthetic materials to repair or regenerate hard tissues.

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Language(s): eng - English
 Dates: 2021-06-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.mtbio.2021.100119
BibTex Citekey: DENG2021100119
Other: OA-Liste?
 Degree: -

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Title: Materials Today Bio
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: - Sequence Number: 100119 Start / End Page: - Identifier: ISSN: 2590-0064