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  Effects of supraphysiological thyroxine administration in healthy controls and patients with depressive disorders

Bauer, M., Baur, H., Berghöfer, A., Ströhle, A., Hellweg, R., Müller-Oerlinghausen, B., et al. (2002). Effects of supraphysiological thyroxine administration in healthy controls and patients with depressive disorders. Journal of Affective Disorders, 68(2-3), 285-294.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A22D-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A22E-3
Genre: Journal Article
Alternative Title : J. Affect. Disord.

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 Creators:
Bauer, M.1, Author
Baur, H1, Author
Berghöfer, A1, Author
Ströhle, A.1, Author
Hellweg, R1, Author
Müller-Oerlinghausen, B1, Author
Baumgartner, A1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: thyroxine; healthy controls; depression; safety; side effects
 Abstract: Background: Thyroxine (T-4) in supraphysiological doses has been found to be an effective supplemental treatment in open studies for refractory mood disorders. Unexpectedly, only minimal side effects have been reported. The goal of the present study was to investigate whether healthy controls and depressed patients differ in their ability to tolerate supraphysiological doses of T-4. Methods: This was an 8-week open study to investigate side effects and levels of thyroid hormones in 13 healthy controls and to compare results with those of 13 patients with refractory depression (unipolar and bipolar) undergoing the similar procedures and T-4 closing regimen in a previous augmentation study. Results: The rate of discontinuation due to side effects was significantly higher in the control group than for the patients (38% versus 0%). The severity of the side effects in the controls increased significantly during treatment with T-4. The side effect scores of the patients were higher than those of the controls prior to T-4 treatment, but did not change significantly during the treatment period. Although the serum concentrations of thyroid hormones rose significantly in both groups, concentrations of fT(3) and fT(4) were significantly higher in the controls. Conclusions: Healthy controls and depressed patients respond significantly differently to supraphysiological T-4 Healthy controls experience higher elevations of thyroid hormones in response to supraphysiological T-4 thus inducing significantly more side effects and discontinuation. Limitations: Open-label study; groups were studied at different times; in contrast to healthy controls, depressed patients were also taking antidepressants. Clinical relevance: Studies provide safety and tolerability data on treatment with supraphysiological doses of T-4. (C) 2002 Elsevier Science BV. All rights reserved

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Language(s): eng - English
 Dates: 2002-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4135
ISI: 000176496500014
 Degree: -

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Title: Journal of Affective Disorders
  Alternative Title : J. Affect. Disord.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 68 (2-3) Sequence Number: - Start / End Page: 285 - 294 Identifier: ISSN: 0165-0327