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  The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease.

Dudek, J., Hartmann, M., & Rehling, P. (2019). The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease. Biochimica et Biophysica Acta, 1865(4), 810-821. doi:10.1016/j.bbadis.2018.08.025.

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 Urheber:
Dudek, J., Autor
Hartmann, M., Autor
Rehling, P.1, Autor           
Affiliations:
1Max Planck Fellow Peter Rehling, ou_1298545              

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Schlagwörter: Barth syndrome; Cardiolipin; Mitochondria; Respiratory chain; Sengers syndrome
 Zusammenfassung: Mitochondria play an essential role in the energy metabolism of the heart. Many of the essential functions are associated with mitochondrial membranes and oxidative phosphorylation driven by the respiratory chain. Mitochondrial membranes are unique in the cell as they contain the phospholipid cardiolipin. The important role of cardiolipin in cardiovascular health is highlighted by several cardiac diseases, in which cardiolipin plays a fundamental role. Barth syndrome, Sengers syndrome, and Dilated cardiomyopathy with ataxia (DCMA) are genetic disorders, which affect cardiolipin biosynthesis. Other cardiovascular diseases including ischemia/reperfusion injury and heart failure are also associated with changes in the cardiolipin pool. Here, we summarize molecular functions of cardiolipin in mitochondrial biogenesis and morphology. We highlight the role of cardiolipin for the respiratory chain, metabolite carriers, and mitochondrial metabolism and describe links to apoptosis and mitochondria specific autophagy (mitophagy) with possible implications in cardiac disease.

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Sprache(n): eng - English
 Datum: 2018-08-262019-04-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.bbadis.2018.08.025
 Art des Abschluß: -

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Titel: Biochimica et Biophysica Acta
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 1865 (4) Artikelnummer: - Start- / Endseite: 810 - 821 Identifikator: -