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  Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning.

Tuoc, T., Dere, E., Radyushkin, K., Pham, L., Nguyen, H., Tonchev, A. B., et al. (2017). Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning. Molecular Neurobiology, 54(6), 4618-4635. doi:10.1007/s12035-016-9948-5.

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 Urheber:
Tuoc, T.1, Autor           
Dere, E., Autor
Radyushkin, K., Autor
Pham, L., Autor
Nguyen, H., Autor
Tonchev, A. B.1, Autor           
Sun, G., Autor
Ronnenberg, A., Autor
Shi, Y., Autor
Staiger, J. F., Autor
Ehrenreich, H., Autor
Stoykova, A.1, Autor           
Affiliations:
1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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Schlagwörter: SWI/SNF complex; BAF170; Hippocampus; Adult neuronal stem cells neurogenesis; Astrogenesis; Learning and memory Adult neuronal stem cells neurogenesis; Astrogenesis; BAF170; Hippocampus; Learning and memory; SWI/SNF
 Zusammenfassung: The BAF chromatin remodeling complex plays an essential role in brain development. However its function in postnatal neurogenesis in hippocampus is still unknown. Here, we show that in postnatal dentate gyrus (DG), the BAF170 subunit of the complex is expressed in radial glial-like (RGL) progenitors and in cell types involved in subsequent steps of adult neurogenesis including mature astrocytes. Conditional deletion of BAF170 during cortical late neurogenesis as well as during adult brain neurogenesis depletes the pool of RGL cells in DG, and promotes terminal astrocyte differentiation. These derangements are accompanied by distinct behavioral deficits, as reflected by an impaired accuracy of place responding in the Morris water maze test, during both hidden platform as well as reversal learning. Inducible deletion of BAF170 in DG during adult brain neurogenesis resulted in mild spatial learning deficits, having a more pronounced effect on spatial learning during the reversal test. These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis and cognition and suggest a specific role of adult neurogenesis in DG in adaptive behavior.

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Sprache(n): eng - English
 Datum: 2016-07-082017-08
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1007/s12035-016-9948-5
 Art des Abschluß: -

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Titel: Molecular Neurobiology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 54 (6) Artikelnummer: - Start- / Endseite: 4618 - 4635 Identifikator: -