Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Caspase recruitment domain 15 gene haplotypes in sarcoidosis

Pabst, S., Golebiewski, M., Herms, S., Karpushova, A., Diaz-Lacava, A., Walier, M., et al. (2011). Caspase recruitment domain 15 gene haplotypes in sarcoidosis. Tissue Antigens, 77(4), 333-337. doi:10.1111/j.1399-0039.2010.01628.x.

Item is

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Pabst, S., Autor
Golebiewski, M., Autor
Herms, S., Autor
Karpushova, A., Autor
Diaz-Lacava, A., Autor
Walier, M.1, Autor           
Zimmer, S., Autor
Cichon, S., Autor
Wienker, T. F.2, Autor           
Nothen, M. M., Autor
Nickenig, G., Autor
Meyer, R., Autor
Skowasch, D., Autor
Grohe, C., Autor
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              
2Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479643              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Adult; Aged; Cohort Studies; European Continental Ancestry Group/genetics; Female; Genetic Predisposition to Disease; Haplotypes/*genetics; Humans; Male; Middle Aged; *Mutation; *Nod2 Signaling Adaptor Protein; *Polymorphism, Single Nucleotide; Sarcoidosis/*genetics/pathology
 Zusammenfassung: Sarcoidosis is a systematic granulomatous disorder. Genetic susceptibility could play a central role in the disease development and progression. In this study, we investigated whether caspase recruitment domain 15 (CARD15) gene haplotypes are associated with the onset or the clinical course of sarcoidosis. Three hundred Caucasian sarcoidosis patients and 381 matched controls were included. Eight haplotype-tagging single nucleotide polymorphisms (SNPs) in the CARD15 gene were examined by mass spectrometry-based SNP genotyping. By haplotype analysis, mutations located in between tested SNPs can also be identified. Therefore, we can conclude that there is no association between the CARD15 gene and the development or a special phenotype of sarcoidosis in our cohort.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2011
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 584833
DOI: 10.1111/j.1399-0039.2010.01628.x
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Tissue Antigens
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 77 (4) Artikelnummer: - Start- / Endseite: 333 - 337 Identifikator: ISSN: 1399-0039 (Electronic) 0001-2815 (Print)