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  Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates

Mamedov, I., Táborský, P., Lubal, P., Laurent, S., Elst, L., Mayer, H., et al. (2009). Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates. European Journal of Inorganic Chemistry, 2009(22), 3298-3306. doi:10.1002/ejic.200900149.

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Mamedov, I1, 2, Autor           
Táborský , P, Autor
Lubal, P, Autor
Laurent, S, Autor
Elst, LV, Autor
Mayer, HA, Autor
Logothetis, NK1, 2, Autor           
Angelovski, G1, 2, Autor           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Zusammenfassung: Two DO3A-based ligands appended with the propylphosphonate side arm and their Ln3+ complexes were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 °C of the Gd3+ complex containing free acid exhibited relative changes of up to 56 in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the decrease in the number of coordinated water molecules from two to one. Temperature-dependent relaxivity and NMRD profiles of Gd3+ complexes showed a fast water exchange and a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application.

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 Datum: 2009-08
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1002/ejic.200900149
BibTex Citekey: 5963
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Titel: European Journal of Inorganic Chemistry
  Kurztitel : Eur. J. Inorg. Chem.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Weinheim, Germany : Wiley-VCH
Seiten: - Band / Heft: 2009 (22) Artikelnummer: - Start- / Endseite: 3298 - 3306 Identifikator: ISSN: 1434-1948
CoNE: https://pure.mpg.de/cone/journals/resource/954926953810_1