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  Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation

Childebayeva, A., Goodrich, J. M., Chesterman, N., Leon-Velarde, F., Rivera-Ch, M., Kiyamu, M., et al. (2021). Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation. Environment International, 155: 106587. doi:10.1016/j.envint.2021.106587.

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 Urheber:
Childebayeva, Ainash1, Autor           
Goodrich, Jaclyn M., Autor
Chesterman, Nathan, Autor
Leon-Velarde, Fabiola, Autor
Rivera-Ch, Maria, Autor
Kiyamu, Melisa, Autor
Brutsaert, Tom D., Autor
Bigham, Abigail W., Autor
Dolinoy, Dana C., Autor
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

Inhalt

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Schlagwörter: Lead (Pb), Hemoglobin, EWAS, Andes, Mining, DNA methylation
 Zusammenfassung: Background
Inorganic lead (Pb) is common in the environment, and is toxic to neurological, renal, and cardiovascular systems. Pb exposure influences the epigenome with documented effects on DNA methylation (DNAm). We assessed the impact of low levels of Pb exposure on DNAm among non-miner individuals from two locations in Peru: Lima, the capital, and Cerro de Pasco, a highland mining town, to study the effects of Pb exposure on physiological outcomes and DNAm.
Methods
Pb levels were measured in whole blood (n = 305). Blood leukocyte DNAm was determined for 90 DNA samples using the Illumina MethylationEPIC chip. An epigenome-wide association study was performed to assess the relationship between Pb and DNAm.
Results
Individuals from Cerro de Pasco had higher Pb than individuals from Lima (p-value = 2.00E-16). Males had higher Pb than females (p-value = 2.36E-04). Pb was positively associated with hemoglobin (p-value = 8.60E-04). In Cerro de Pasco, blood Pb decreased with the distance from the mine (p-value = 0.04), and association with soil Pb was approaching significance (p-value = 0.08). We identified differentially methylated positions (DMPs) associated with genes SOX18, ZMIZ1, and KDM1A linked to neurological function. We also found 45 differentially methylated regions (DMRs), seven of which were associated with genes involved in metal ion binding and nine to neurological function and development.
Conclusions
Our results demonstrate that even low levels of Pb can have a significant impact on the body including changes to DNAm. We report associations between Pb and hemoglobin, Pb and distance from mining, and between blood and soil Pb. We also report associations between loci- and region-specific DNAm and Pb.

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Sprache(n): eng - English
 Datum: 2021-102021-04-30
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: 1. Introduction
2. Materials and Methods
2.1. Study population
2.2. Phenotypic assessment and Pb exposure assessment
2.3. Geocoding and soil Pb interpolation
2.4. DNA methylation
2.5. Statistical analyses
3. Results
3.1. Study design and participant characteristics
3.2. Lead levels are associated with study group, sex, and Hb
3.3. Blood lead is negatively correlated with distance from the mine and positively correlated with soil lead in Cerro de Pasco
3.4. DNA methylation and blood lead
4. Discussion
5. Limitations
6. Conclusions
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.envint.2021.106587
Anderer: shh2921
 Art des Abschluß: -

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Titel: Environment International
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: New York : Pergamon
Seiten: - Band / Heft: 155 Artikelnummer: 106587 Start- / Endseite: - Identifikator: ISSN: 0160-4120
CoNE: https://pure.mpg.de/cone/journals/resource/954925477499