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  Strain history dependence of the nonlinear stress response of fibrin and collagen networks

Muenster, S., Jawerth, L. M., Leslie, B. A., Weitz, J. I., Fabry, B., & Weitz, D. A. (2013). Strain history dependence of the nonlinear stress response of fibrin and collagen networks. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(30), 12197-12202. doi:10.1073/pnas.1222787110.

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 Creators:
Muenster, Stefan1, Author              
Jawerth, Louise M.2, Author
Leslie, Beverly A.2, Author
Weitz, Jeffrey I.2, Author
Fabry, Ben2, Author
Weitz, David A.2, Author
Affiliations:
1International Max Planck Research School, Max Planck Institute for the Science of Light, Max Planck Society, ou_2364697              
2external, ou_persistent22              

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Free keywords: MECHANICAL-PROPERTIES; VISCOELASTIC BEHAVIOR; FINE CLOTS; RHEOLOGY; BINDING; GEL; ELASTICITY; MATRICES; COMPLEX; FIBERSScience & Technology - Other Topics; ECM; nonlinear rheology; factor XIII; blood clot;
 Abstract: We show that the nonlinear mechanical response of networks formed from un-cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response arises from a shift of a characteristic nonlinear stress-strain relationship to higher strains. Therefore, the imposed loading does not weaken the underlying matrices but instead delays the occurrence of the strain stiffening. Using confocal microscopy, we present direct evidence that this behavior results from persistent lengthening of individual fibers caused by an interplay between fiber stretching and fiber buckling when the networks are repeatedly strained. Moreover, we show that covalent cross-linking of fibrin or collagen inhibits the shift of the nonlinear material response, suggesting that the molecular origin of individual fiber lengthening may be slip of monomers within the fibers. Thus, a fibrous architecture in combination with constituents that exhibit internal plasticity creates a material whose mechanical response adapts to external loading conditions. This design principle may be useful to engineer novel materials with this capability.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000322112300026
DOI: 10.1073/pnas.1222787110
 Degree: -

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Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Source Genre: Journal
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Publ. Info: 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA : NATL ACAD SCIENCES
Pages: - Volume / Issue: 110 (30) Sequence Number: - Start / End Page: 12197 - 12202 Identifier: ISSN: 0027-8424