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  SLC25A51 is a mammalian mitochondrial NAD+ transporter

Luongo, T. S., Eller, J. M., Lu, M.-J., Niere, M., Raith, F., Perry, C., et al. (2020). SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature, 588, 174-179. doi:10.1038/s41586-020-2741-7.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-6FEB-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-90EA-E
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 Creators:
Luongo, Timothy S., Author
Eller, Jared M., Author
Lu, Mu-Jie, Author
Niere, Marc, Author
Raith, Fabio1, Author           
Perry, Caroline, Author
Bornstein, Marc R., Author
Oliphint, Paul, Author
Wang, Lin, Author
McReynolds, Melanie R., Author
Migaud, Marie E., Author
Rabinowitz, Joshua D., Author
Johnson, F. Brad, Author
Johnsson, Kai2, Author           
Ziegler, Mathias, Author
Cambronne, Xiaolu A., Author
Baur, Joseph A., Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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 Abstract: Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in yeast and plants1,2, but their existence in mammals remains controversial3,4,5. Here we demonstrate that mammalian mitochondria can take up intact NAD+, and identify SLC25A51 (also known as MCART1)—an essential6,7 mitochondrial protein of previously unknown function—as a mammalian mitochondrial NAD+ transporter. Loss of SLC25A51 decreases mitochondrial—but not whole-cell—NAD+ content, impairs mitochondrial respiration, and blocks the uptake of NAD+ into isolated mitochondria. Conversely, overexpression of SLC25A51 or SLC25A52 (a nearly identical paralogue of SLC25A51) increases mitochondrial NAD+ levels and restores NAD+ uptake into yeast mitochondria lacking endogenous NAD+ transporters. Together, these findings identify SLC25A51 as a mammalian transporter capable of importing NAD+ into mitochondria.

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Language(s): eng - English
 Dates: 2019-12-222020-09-012020-09-092020-12-01
 Publication Status: Issued
 Pages: 22
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41586-020-2741-7
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 588 Sequence Number: - Start / End Page: 174 - 179 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238