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Abstract:
Kinetochores are protein scaffolds coordinating the process of
chromosome segregation in mitosis. Kinetochore components are organized
in functionally and topologically distinct domains that are designed to
connect the sister chromatids to the mitotic spindle. The inner
kinetochore proteins are in direct contact with the centromeric DNA,
whilst the outer kinetochore proteins are responsible for binding to
spindle microtubules. The conserved Ndc80 complex is implicated in
several essential outer kinetochore functions, including microtubule
binding and control of a safety device known as the spindle assembly
checkpoint. Here, we describe how current work is contributing to
unravel the complex endeavors of this essential kinetochore complex. (c)
2007 Federation of European Biochemical Societies. Published by Elsevier
B.V. All rights reserved.
