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Zusammenfassung:
We report a methodology which enables preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaken synthetic transformations, despite structural changes. The in vivo MRI studies in rat cerebral cortex indicate that diffusion property of dendrimeric contrast agent has great advantages as compared to its monomeric equivalent.
