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  The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity

Huhtaniemi, I. T., Eskola, V., Pakarinen, P., Matikainen, T., & Sprengel, R. (1992). The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Molecular and Cellular Endocrinology, 88(1-3), 55-66. doi:10.1016/0303-7207(92)90009-U.

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MolCellEndocrinol_ 88_1992_55.pdf (beliebiger Volltext), 2MB
 
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 Urheber:
Huhtaniemi, Ilpo T., Autor
Eskola, Vesa, Autor
Pakarinen, Pirjo, Autor
Matikainen, Tiina, Autor
Sprengel, Rolf1, 2, 3, Autor           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497741              
3Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              

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Schlagwörter: Follicle-stimulating hormone receptor; Luteinizing hormone receptor; Promoter; Gene structure; Transcription initiation site; Luciferase reporter gene
 Zusammenfassung: The putative promoter regions of the murine follicle-stimulating hormone (FSH) and luteinizing hormone (LH) receptor genes were isolated and used to map transcription initiation sites for both genes. For the FSH receptor gene, a major transcription initiation site was found 534 nucleotides upstream, and for the LH receptor gene 310 nucleotides upstream of the corresponding translation initiation codons. In addition, several alternative minor transcription initiation sites were observed for both genes. The nucleotide sequences of the promoter regions revealed no canonical promoter elements, such as TATA and CCAAT consensus sites 5' of the main transcriptional start sites. The isolated promoter segments for both receptor genes showed low functional activity as verified in transient expression studies in immature rat granulosa cells using the luciferase coding region as the reporter for promoter activity. Both promoter elements seem to be still under tissue specific control, since neither LH receptor nor FSH receptor promoter activity was detectable in another cell line (CHO) investigated.

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Sprache(n): eng - English
 Datum: 1992-03-091992-06-122003-01-061992-10
 Publikationsstatus: Erschienen
 Seiten: 12
 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
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Titel: Molecular and Cellular Endocrinology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 88 (1-3) Artikelnummer: - Start- / Endseite: 55 - 66 Identifikator: ISSN: 0303-7207
CoNE: https://pure.mpg.de/cone/journals/resource/954925511429