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  A language-based sum score for the course and therapeutic intervention in primary progressive aphasia

Semler, E., Anderl-Straub, S., Uttner, I., Diehl-Schmid, J., Danek, A., Einsiedler, B., et al. (2018). A language-based sum score for the course and therapeutic intervention in primary progressive aphasia. Alzheimer's Research & Therapy, 10: 41. doi:10.1186/s13195-018-0345-3.

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 Urheber:
Semler, Elisa 1, Autor
Anderl-Straub, Sarah1, Autor
Uttner, Ingo1, Autor
Diehl-Schmid, Janine2, Autor
Danek, Adrian3, Autor
Einsiedler, Beate4, Autor
Fassbender, Klaus5, Autor
Fliessbach, Klaus6, Autor
Huppertz, Hans-Jürgen7, Autor
Jahn, Holger8, Autor
Kornhuber, Johannes9, Autor
Landwehrmeyer, Bernhard1, Autor
Lauer, Martin10, Autor
Muche, Rainer4, Autor
Prudlo, Johannes11, 12, Autor
Schneider, Anja13, Autor
Schroeter, Matthias L.14, 15, Autor           
Ludolph, Albert C.1, Autor
Otto, Markus1, Autor
FTLD consortium, Autor              
Affiliations:
1Department of Neurology, Ulm University, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, TU Munich, Germany, ou_persistent22              
3Department of Neurology, Ludwig Maximilians University Munich, Germany, ou_persistent22              
4Institute of Epidemiology and Medical Biometry, Ulm University, Germany, ou_persistent22              
5Department of Neurology, Saarland University Homburg, Germany, ou_persistent22              
6Department of Psychiatry and Psychotherapy, University Bonn, Germany, ou_persistent22              
7Swiss Epilepsy Centre, Zurich, Switzerland, ou_persistent22              
8Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
9Department of Psychology and Psychotherapy, Friedrich Alexander University Erlangen, Germany, ou_persistent22              
10Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Germany, ou_persistent22              
11Department of Neurology, University Medicine Rostock, Germany, ou_persistent22              
12German Center for Neurodegenerative Diseases, Rostock, Germany, ou_persistent22              
13Department of Psychiatry and Psychotherapy, Georg August University, Göttingen, Germany, ou_persistent22              
14Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              
15Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: Aphasia; Assessment of cognitive disorders/dementia; Cognitive neuropsychology in dementia; Frontotemporal dementia; Volumetric MR
 Zusammenfassung: BACKGROUND:
With upcoming therapeutic interventions for patients with primary progressive aphasia (PPA), instruments for the follow-up of patients are needed to describe disease progression and to evaluate potential therapeutic effects. So far, volumetric brain changes have been proposed as clinical endpoints in the literature, but cognitive scores are still lacking. This study followed disease progression predominantly in language-based performance within 1 year and defined a PPA sum score which can be used in therapeutic interventions.
METHODS:
We assessed 28 patients with nonfluent variant PPA, 17 with semantic variant PPA, 13 with logopenic variant PPA, and 28 healthy controls in detail for 1 year. The most informative neuropsychological assessments were combined to a sum score, and associations between brain atrophy were investigated followed by a sample size calculation for clinical trials.
RESULTS:
Significant absolute changes up to 20% in cognitive tests were found after 1 year. Semantic and phonemic word fluency, Boston Naming Test, Digit Span, Token Test, AAT Written language, and Cookie Test were identified as the best markers for disease progression. These tasks provide the basis of a new PPA sum score. Assuming a therapeutic effect of 50% reduction in cognitive decline for sample size calculations, a number of 56 cases is needed to find a significant treatment effect. Correlations between cognitive decline and atrophy showed a correlation up to r = 0.7 between the sum score and frontal structures, namely the superior and inferior frontal gyrus, as well as with left-sided subcortical structures.
CONCLUSION:
Our findings support the high performance of the proposed sum score in the follow-up of PPA and recommend it as an outcome measure in intervention studies.

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Sprache(n): eng - English
 Datum: 2017-11-042018-01-222018-04-25
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1186/s13195-018-0345-3
PMID: 29695300
PMC: PMC5922300
 Art des Abschluß: -

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Projektinformation

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Projektname : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : O1GI1007A
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : SOPHIA
Grant ID : -
Förderprogramm : -
Förderorganisation : Joint Programme – Neurodegenerative Disease Research (JPND)
Projektname : BiomarkAPD
Grant ID : -
Förderprogramm : -
Förderorganisation : Joint Programme – Neurodegenerative Disease Research (JPND)
Projektname : PreFrontAls
Grant ID : 01ED1512
Förderprogramm : -
Förderorganisation : oint Programme – Neurodegenerative Disease Research (JPND)
Projektname : Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone / FAIR-PARK II
Grant ID : 633190
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : D.3830 ; D.5009
Förderprogramm : -
Förderorganisation : Foundation of the state of Baden-Württemberg

Quelle 1

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Titel: Alzheimer's Research & Therapy
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: BioMed Central
Seiten: - Band / Heft: 10 Artikelnummer: 41 Start- / Endseite: - Identifikator: ISSN: 1758-9193
CoNE: https://pure.mpg.de/cone/journals/resource/1758-9193