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Abstract:
Functional MRI has been used to map task-related and resting-state brain networks with the assumption that the neurovascular coupling underlay the fMRI signal. Previously, a line-scanning fMRI method was developed to map BOLD and CBV fMRI signal which were primarily located at individual arteriole and venule voxels. It demonstrated that the
vascular hemodynamic signal coupled to neural activity could be directly mapped with the single-vessel fMRI method [3]. However, line-scanning fMRI method required massive
averaging of the fMRI signal across multiple stimulation on/off blocks which couldn't meet requirements of resting state fMRI. In this work, we implemented the stead-state
free precession (SSFP) method to obtain vessel-specific task-related and resting state fMRI signal with vascular specificity in rats. This work established the basic platform to map the BOLD/CBV fMRI-based vascular network connectivity in rats. In addition, to verify and translate the vascular network connectivity, we implemented conventional EPI to visual cortex of human brain in 3T and 9.4T scanners.
