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  BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Hiepen, C., Jatzlau, J., Hildebrandt, S., Kampfrath, B., Göktas, M., Murgai, A., et al. (2019). BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biology, 17(12): e3000557. doi:10.1371/journal.pbio.3000557.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0005-6469-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-69C7-5
Genre: Journal Article

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 Creators:
Hiepen, Christian, Author
Jatzlau, Jerome, Author
Hildebrandt, Susanne, Author
Kampfrath, Branka, Author
Göktas, Melis1, Author           
Murgai, Arunima, Author
Camacho, Cuellar, Author
Luis, Jose, Author
Haag, Rainer, Author
Ruppert, Clemens, Author
Sengle, Gerhard, Author
Cavalcanti-Adam, Elisabetta Ada, Author
Blank, Kerstin G.1, Author           
Knaus, Petra, Author
Affiliations:
1Kerstin Blank, Mechano(bio)chemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2301698              

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Free keywords: SMAD signaling; Cloning; Phosphorylatoin; BMP signaling; Intergins; Sell signaling; Immunohistochemistry techniques; Endothelial cells
 Abstract: Balanced TGFβ/BMP-signaling is essential for tissue formation and homeostasis; this study shows that the receptor BMPR2 serves as gatekeeper of this balance, protecting cells from increased TGFβ-responses and integrin-mediated mechanotransduction.

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Language(s): eng - English
 Dates: 2019-12-112019
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pbio.3000557
 Degree: -

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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 17 (12) Sequence Number: e3000557 Start / End Page: - Identifier: ISSN: 1544-9173