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  Ratiometric Method for Rapid Monitoring of Biological Processes Using Bioresponsive MRI Contrast Agents

Gündüz, S., Savić, T., Pohmann, R., Logothetis, N., Scheffler, K., & Angelovski, G. (2016). Ratiometric Method for Rapid Monitoring of Biological Processes Using Bioresponsive MRI Contrast Agents. ACS Sensors, 1(5), 483-487. doi:10.1021/acssensors.6b00011.

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Gündüz, S1, 2, Autor           
Savić, T1, 2, Autor           
Pohmann, R1, 3, Autor           
Logothetis, NK1, 4, Autor           
Scheffler, K1, 3, Autor           
Angelovski, G1, 2, Autor           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
4Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: Bioresponsive MRI contrast agents hold great potential for non-invasive tracking of essential biological processes. Consequently, a number of MR sensors for several imaging protocols have been developed, attempting to produce the maximal signal difference for a given event. Here we introduce an approach which could substantially improve the detection of physiological events with fast kinetics. We developed a nanosized, calcium-sensitive dendrimeric probe that changes longitudinal and transverse relaxation times with different magnitudes. The change in their ratio is rapidly recorded by means of a balanced steady-state free precession (bSSFP) imaging protocol. The employed methodology results in an almost four times greater signal gain per unit of time as compared to conventional T1-weighted imaging with small sized contrast agents. Furthermore, it is suitable for high resolution functional MRI at high magnetic fields. This methodology could evolve into a valuable tool for rapid monitoring of various biological events.

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 Datum: 2016-06
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1021/acssensors.6b00011
BibTex Citekey: GunduzSPLSA2016
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Titel: ACS Sensors
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 1 (5) Artikelnummer: - Start- / Endseite: 483 - 487 Identifikator: -