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  The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion

Flemming, A., Brummer, T., Reth, M., & Jumaa, H. (2003). The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nature Immunology, 4(1), 38-43.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9588-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9589-9
Genre: Journal Article

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 Creators:
Flemming, Alexandra1, Author           
Brummer, Tilman2, Author
Reth, Michael1, Author           
Jumaa, Hassan1, Author           
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              
2Max Planck Society, ou_persistent13              

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 Abstract: Mice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers of mature B cells, but an increased pre-B cell compartment. We show here that compared to wild-type cells, SLP-65-/- pre-B cells show an enhanced ex vivo proliferative capacity. This proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In addition, SLP-65-/- mice have a high incidence of pre-B cell lymphoma. Reintroduction of SLP-65 into SLP-65-/- pre-B cells led to pre-BCR down-regulation and enhanced differentiation. Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor.

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Language(s): eng - English
 Dates: 2003-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 18573
ISI: 000180053000012
 Degree: -

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Title: Nature Immunology
  Alternative Title : Nat. Immunol.
Source Genre: Journal
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Pages: - Volume / Issue: 4 (1) Sequence Number: - Start / End Page: 38 - 43 Identifier: ISSN: 1529-2908