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  Outcomes of stable and unstable patterns of subjective cognitive decline: Results from the Leipzig Longitudinal Study of the Aged (LEILA75+)

Roehr, S., Villringer, A., Angermeyer, M. C., Luck, T., & Riedel-Heller, S. (2016). Outcomes of stable and unstable patterns of subjective cognitive decline: Results from the Leipzig Longitudinal Study of the Aged (LEILA75+). BMC Geriatrics, 16: 180. doi:10.1186/s12877-016-0353-8.

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 Creators:
Roehr, Susanne1, Author
Villringer, Arno2, 3, Author           
Angermeyer, Matthias C.4, 5, Author
Luck, Tobias1, 6, Author
Riedel-Heller, Steffi1, Author
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Center for Public Mental Health, Cagliari, Italy, ou_persistent22              
5Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy, ou_persistent22              
6Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Subjective cognitive decline; Mild cognitive impairment; Dementia; Alzheimer’s disease; Progression risk; Cohort studies; Outcomes
 Abstract: Background Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all individuals with SCD progress. Stability of SCD, i.e., repeated reports of SCD, could contribute to identify individuals at risk, as stable SCD may more likely reflect the continuous neurodegenerative process of Alzheimer’s and other dementias. Methods Cox regression analyses were used to assess the association between stability of SCD and progression to MCI and dementia in data derived from the population-based Leipzig Longitudinal Study of the Aged (LEILA75+). Results Of 453 cognitively unimpaired individuals with a mean age of 80.5 years (SD = 4.2), 139 (30.7 %) reported SCD at baseline. Over the study period (M = 4.8 years, SD = 2.2), 84 (18.5 %) individuals had stable SCD, 195 (43.1 %) unstable SCD and 174 (38.4 %) never reported SCD. Stable SCD was associated with increased risk of progression to MCI and dementia (unadjusted HR = 1.8, 95 % CI = 1.2–2.6; p < .01), whereas unstable SCD yielded a decreased progression risk (unadjusted HR = 0.5, 95 % CI = 0.4–0.7; p < .001) compared to no SCD. When adjusted for baseline cognitive functioning, progression risk in individuals with stable SCD was significantly increased in comparison to individuals with unstable SCD, but not compared to individuals without SCD. Conclusions Our results, though preliminary, suggest that stable SCD, i.e., repeated reports of SCD, may yield an increased risk of progression to MCI and dementia compared to unstable SCD. Baseline cognitive scores, though within a normal range, seem to be a driver of progression in stable SCD. Future research is warranted to investigate whether stability could hold as a SCD research feature.

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Language(s): eng - English
 Dates: 2016-04-212016-10-252016-11-04
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1186/s12877-016-0353-8
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Title: BMC Geriatrics
Source Genre: Journal
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Publ. Info: London : BioMed Central
Pages: - Volume / Issue: 16 Sequence Number: 180 Start / End Page: - Identifier: ISSN: 1471-2318
CoNE: https://pure.mpg.de/cone/journals/resource/1471-2318