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  Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes

Kuner, T., Schöpfer, R., & Korpi, E. R. (1993). Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. NeuroReport, 5(3), 297-300. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/7905294.

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Alternativer Titel : Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes

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NeuroRep_5_1994_297.pdf (beliebiger Volltext), 287KB
 
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 Urheber:
Kuner, Thomas1, 2, Autor           
Schöpfer, Ralf1, Autor           
Korpi, Esa R., Autor
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Zusammenfassung: Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C subunit combinations. Concentration-dependent inhibition was observed at ethanol concentrations of > or = 50 mM both in Ca(2+)-containing and Ca(2+)-deficient, Ba(2+)-containing Mg(2+)-free media. The NR1-NR2C channels were slightly less sensitive to ethanol inhibition than the other heteromeric channels in Ca(2+)-deficient, Ba(2+)-containing medium. The inhibition was unaffected by the clamping-voltage and by a mutation [NR1-NR2A(N595Q)] that prevents the Mg(2+)-blockade of the channels, indicating that the mechanism of action of ethanol differs from that of Mg2+. The results are consistent with the hypothesis that the NMDA receptor subtypes can mediate many behavioural actions of ethanol.

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Sprache(n): eng - English
 Datum: 1993-09-131993-09-261993-12-13
 Publikationsstatus: Erschienen
 Seiten: 4
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 666814
URI: https://www.ncbi.nlm.nih.gov/pubmed/7905294
Anderer: 4010
 Art des Abschluß: -

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Titel: NeuroReport
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford, UK : Rapid Communications of Oxford Ltd.
Seiten: - Band / Heft: 5 (3) Artikelnummer: - Start- / Endseite: 297 - 300 Identifikator: ISSN: 0959-4965
CoNE: https://pure.mpg.de/cone/journals/resource/954925578070