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  In vivo visualization of pancreatic islets in the mouse

Balla, D., Gottschalk, S., Shajan, G., Ueberberg, S., Schneider, S., Pohmann, R., et al. (2011). In vivo visualization of pancreatic islets in the mouse. In 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011) (pp. 665).

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-BC18-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-4C2D-8
Genre: Meeting Abstract

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ISMRM-2011-665.pdf (Abstract), 758KB
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 Creators:
Balla, D1, 2, Author           
Gottschalk, S1, 2, Author           
Shajan, G1, 2, Author           
Ueberberg, S, Author
Schneider, S, Author
Pohmann, R1, 2, Author           
Engelmann, J1, 2, Author           
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Detection of single pancreatic islets has many applications in diabetes research, but can be achieved in vivo with proton MRI only after transplantation of ex vivo labeled islets. Recently, successful visualization of islets in the excised mouse pancreas at 16.4T following i.v. injection of a novel beta-cell specific paramagnetic contrast agent was reported. Here we present the methodical optimization for in vivo experiments. Signal efficient 2D acquisition methods were considered. Best results were obtained with a two slice navigator based sequence. Single islets are visualized for the first time in vivo in mice after i.v. administration of a labeling agent.

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 Dates: 2011-05
 Publication Status: Issued
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 Identifiers: BibTex Citekey: BallaGGPE2011
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Title: 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011)
Place of Event: Montréal, Canada
Start-/End Date: 2011-05-07 - 2011-05-13

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Title: 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 665 Identifier: -