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  Regulated expression of human growth hormone genes in mouse cells

Robins, D. M., Paek, I., Axel, R., & Seeburg, P. H. (1982). Regulated expression of human growth hormone genes in mouse cells. Cell, 29(2), 623-631. doi:10.1016/0092-8674(82)90178-7.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-F23B-D Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F23C-C
Genre: Journal Article

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 Creators:
Robins, D. M., Author
Paek, I., Author
Axel, R., Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: We have asked whether there are sequences around the human growth hormone gene that render this gene responsive to induction by glucocorticoid hormones. Recombinant clones encoding human growth hormone were introduced into the chromosome of murine fibroblasts by cotransformation. Exposure of cotransformants to glucocorticoids results in a three to five fold induction of human growth hormone mRNA and a similar induction in secreted human growth hormone protein. The DNA sequences required for induction reside within 500 nucleotides of 5'-flanking DNA. Fusion of this segment of 5'-flanking DNA to the structural gene sequences of a hormone-insensitive gene, such as thymidine kinase, now renders this gene responsive to glucocorticoid induction.

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Language(s): eng - English
 Dates: 1982-02-011982-03-181982-06
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0092-8674(82)90178-7
URI: https://www.ncbi.nlm.nih.gov/pubmed/7116452
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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 29 (2) Sequence Number: - Start / End Page: 623 - 631 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183