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  Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication

Senden, M., Reuter, N., van den Heuvel, M. P., Goebel, R., Deco, G., & Gilson, M. (2018). Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication. Human Brain Mapping, 39(3), 1246-1262. doi:10.1002/hbm.23913.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-844E-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-533B-C
Genre: Journal Article

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 Creators:
Senden, Mario1, 2, Author
Reuter, Niels3, 4, Author
van den Heuvel, Martijn P.5, Author
Goebel, Rainer1, 2, 6, Author
Deco, Gustavo7, 8, 9, 10, Author           
Gilson, Matthieu7, Author
Affiliations:
1Department of Cognitive Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
2Maastricht Brain Imaging Center (M-BIC), Maastricht University, the Netherlands, ou_persistent22              
3Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands, ou_persistent22              
6Department of Neuroimaging and Neuromodeling, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
7Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
8Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
9Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
10School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Computational modeling; Dynamics; Effective connectivity; fMRI; Network analysis; Resting state; Rich club; Task state
 Abstract: Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs—referred to as the rich club—has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective connectivity (EC) of the structural rich club and relate these to whole-cortex dynamics and network reconfigurations. We find that the cortical rich club exhibits an increase in outgoing EC during task performance as compared with rest while incoming connectivity remains constant. Increased outgoing connectivity targets a sparse set of peripheral regions with specific regions strongly overlapping between tasks. At the same time, community detection analyses reveal massive reorganizations of interactions among peripheral regions, including those serving as target of increased rich club output. This suggests that while peripheral regions may play a role in several tasks, their concrete interplay might nonetheless be task-specific. Furthermore, we observe that whole-cortex dynamics are faster during task as compared with rest. The decoupling effects usually accompanying faster dynamics appear to be counteracted by the increased rich club outgoing EC. Together our findings speak to a gating mechanism of the rich club that supports fast-paced information exchange among relevant peripheral regions in a task-specific and goal-directed fashion, while constantly listening to the whole network.

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Language(s): eng - English
 Dates: 2017-11-232017-09-052017-11-302018-02-092018-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.23913
PMID: 29222818
Other: Epub 2017
 Degree: -

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Project name : Cracking the columnar-level code in the visual hierarchy: Ultra high-field functional MRI, neuro-cognitive modelling and high-resolution brain-computer interfaces / COLUMNARCODECRACKING
Grant ID : 269853
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Biological neural networks: from structure to function / NeuArc2Fun
Grant ID : 656547
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : The Human Brain Project / HBP
Grant ID : 604102
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : 452‐16‐015
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)

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Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 39 (3) Sequence Number: - Start / End Page: 1246 - 1262 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686