Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Characterization of magnetic nanoparticles from Magnetospirillum Gryphiswaldense as potential theranostics tools.

Orlando, T., Mannucci, S., Fantechi, E., Conti, G., Tambalo, S., Busato, A., et al. (2016). Characterization of magnetic nanoparticles from Magnetospirillum Gryphiswaldense as potential theranostics tools. Contrast Media and Molecular Imaging, 11(2), 139-145. doi:10.1002/cmmi.1673.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
2281448.pdf (Verlagsversion), 310KB
 
Datei-Permalink:
-
Name:
2281448.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (UNKNOWN id 303; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Orlando, T.1, Autor           
Mannucci, S., Autor
Fantechi, E., Autor
Conti, G., Autor
Tambalo, S., Autor
Busato, A., Autor
Innocenti, C., Autor
Ghin, L., Autor
Bassi, R., Autor
Arosio, P., Autor
Orsini, F., Autor
Sangregorio, C., Autor
Corti, M., Autor
Casula, M. F., Autor
Marzola, P., Autor
Lascialfari, A., Autor
Sbarbati, A., Autor
Affiliations:
1Research Group of Electron Paramagnetic Resonance, MPI for Biophysical Chemistry, Max Planck Society, ou_578606              

Inhalt

einblenden:
ausblenden:
Schlagwörter: magnetosomes; relaxometry; contrast agent; MRI; hyperthermia; theranostics
 Zusammenfassung: We investigated the theranostic properties of magnetosomes (MNs) extracted from magnetotactic bacteria, promising for nanomedicine applications. Besides a physico-chemical characterization, their potentiality as mediators for magnetic fluid hyperthermia and contrast agents for magnetic resonance imaging, both in vitro and in vivo, are here singled out. The MNs, constituted by magnetite nanocrystals arranged in chains, show a superparamagnetic behaviour and a clear evidence of Verwey transition, as signature of magnetite presence. The phospholipid membrane provides a good protection against oxidation and the MNs oxidation state is stable over months. Using an alternate magnetic field, the specific absorption rate was measured, resulting among the highest reported in literature. The MRI contrast efficiency was evaluated by means of the acquisition of complete NMRD profiles. The transverse relaxivity resulted as high as the one of a former commercial contrast agent. The MNs were inoculated into an animal model of tumour and their presence was detected by magnetic resonance images two weeks after the injection in the tumour mass.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2015-11-242016-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/cmmi.1673
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Contrast Media and Molecular Imaging
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 11 (2) Artikelnummer: - Start- / Endseite: 139 - 145 Identifikator: -