English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A

Meyer, H. S., Schwarz, D., Wimmer, V. C., Schmitt, A. C., Kerr, J. N., Sakmann, B., et al. (2011). Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16807-12. doi:10.1073/pnas.1113648108.

Item is

Files

show Files
hide Files
:
Meyer-2011-Inhibitory interneur.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
Meyer-2011-Inhibitory interneur.pdf
Description:
-
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Meyer, H. S., Author
Schwarz, D., Author
Wimmer, V. C., Author
Schmitt, A. C., Author
Kerr, J. N.1, Author
Sakmann, B., Author
Helmstaedter, M., Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: Animals Brain Mapping/*methods Fluorescence Glutamate Decarboxylase Immunohistochemistry Interneurons/*physiology Microscopy, Confocal Neural Inhibition/*physiology Rats Rats, Wistar Somatosensory Cortex/*cytology/physiology
 Abstract: Although physiological data on microcircuits involving a few inhibitory neurons in the mammalian cerebral cortex are available, data on the quantitative relation between inhibition and excitation in cortical circuits involving thousands of neurons are largely missing. Because the distribution of neurons is very inhomogeneous in the cerebral cortex, it is critical to map all neurons in a given volume rather than to rely on sparse sampling methods. Here, we report the comprehensive mapping of interneurons (INs) in cortical columns of rat somatosensory cortex, immunolabeled for neuron-specific nuclear protein and glutamate decarboxylase. We found that a column contains ~2,200 INs (11.5% of ~19,000 neurons), almost a factor of 2 less than previously estimated. The density of GABAergic neurons was inhomogeneous between layers, with peaks in the upper third of L2/3 and in L5A. IN density therefore defines a distinct layer 2 in the sensory neocortex. In addition, immunohistochemical markers of IN subtypes were layer-specific. The "hot zones" of inhibition in L2 and L5A match the reported low stimulus-evoked spiking rates of excitatory neurons in these layers, suggesting that these inhibitory hot zones substantially suppress activity in the neocortex.

Details

show
hide
Language(s):
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 21949377
DOI: 10.1073/pnas.1113648108
ISSN: 1091-6490 (Electronic)
ISSN: 0027-8424 (Linking)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
  Alternative Title : Proc. Natl. Acad. Sci. USA
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 108 (40) Sequence Number: - Start / End Page: 16807 - 12 Identifier: -