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要旨:
Different approaches for a mammalian cell culture based production process for influenza vaccines are currently in development. Each approach needs optimization based on analytical data collected from many small scale experiments. In the presentation results for different cultivation methods (rollerbottles, stirred tank or wave bioreactor microcarrier system) for a production process with adherent MDCK cells are discussed. Analytical data on cell numbers, metabolism, host cell protein level, cell cycle and virus titer are shown.
