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  Stereoselective Synthesis of E,Z-Configured 1,3-Dienes by Ring-Closing Metathesis. Application to the Total Synthesis of Lactimidomycin

Gallenkamp, D., & Fürstner, A. (2011). Stereoselective Synthesis of E,Z-Configured 1,3-Dienes by Ring-Closing Metathesis. Application to the Total Synthesis of Lactimidomycin. Journal of the American Chemical Society, 133(24), 9232-9235. doi:10.1021/ja2031085.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-AE91-3 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-AE92-1
Genre: Journal Article

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ja2031085_si_001.pdf (Supplementary material), 5MB
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 Creators:
Gallenkamp, Daniel1, Author           
Fürstner, Alois1, Author           
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1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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 Abstract: Strategic positioning of a silyl group on the diene unit of a diene-ene substrate allows rigorous regio- and stereocontrol to be exerted during metathesis-based macrocyclization reactions. The versatility of this concise approach to E,Z-configured 1,3-dienes of ring sizes of 12 or larger is demonstrated by an application to the total synthesis of lactimidomycin, a potent translation and cell-migration inhibitor.

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Language(s): eng - English
 Dates: 2011-04-052011-05-232011-06-22
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ja2031085
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Title: Journal of the American Chemical Society
  Other : J. Am. Chem. Soc.
  Abbreviation : JACS
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 133 (24) Sequence Number: - Start / End Page: 9232 - 9235 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870