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  A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

Noda, M., Suzuki, H., Numa, S., & Stühmer, W. (1989). A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II. FEBs Letters, 259(1), 213-216. doi:10.1016/0014-5793(89)81531-5.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-B78D-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-B795-5
Genre: Journal Article

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 Creators:
Noda, M., Author
Suzuki, H., Author
Numa, S., Author
Stühmer, W.1, Author           
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage-clamp in Xenopus oocytes injected with the corresponding cDNA-derived mRNA.

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Language(s): eng - English
 Dates: 1989-12
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0014-5793(89)81531-5
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Title: FEBs Letters
Source Genre: Journal
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Pages: - Volume / Issue: 259 (1) Sequence Number: - Start / End Page: 213 - 216 Identifier: -