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  A genome sequence from a modern human skull over 45,000 years old from Zlatý kůň in Czechia

Prüfer, K., Posth, C., Yu, H., Stoessel, A., Spyrou, M. A., Deviese, T., et al. (2021). A genome sequence from a modern human skull over 45,000 years old from Zlatý kůň in Czechia. Nature Ecology & Evolution, s41559-021-01443-x. doi:10.1038/s41559-021-01443-x.

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 Creators:
Prüfer, Kay1, Author              
Posth, Cosimo1, Author              
Yu, He1, Author              
Stoessel, Alexander1, Author              
Spyrou, Maria A.1, Author              
Deviese, Thibaut, Author
Mattonai, Marco, Author
Ribechini, Erika, Author
Higham, Thomas, Author
Velemínský, Petr, Author
Brůžek, Jaroslav, Author
Krause, Johannes1, 2, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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Free keywords: Evolutionary biology, Evolutionary genetics
 Abstract: Modern humans expanded into Eurasia more than 40,000 years ago following their dispersal out of Africa. These Eurasians carried ~2–3% Neanderthal ancestry in their genomes, originating from admixture with Neanderthals that took place sometime between 50,000 and 60,000 years ago, probably in the Middle East. In Europe, the modern human expansion preceded the disappearance of Neanderthals from the fossil record by 3,000–5,000 years. The genetic makeup of the first Europeans who colonized the continent more than 40,000 years ago remains poorly understood since few specimens have been studied. Here, we analyse a genome generated from the skull of a female individual from Zlatý kůň, Czechia. We found that she belonged to a population that appears to have contributed genetically neither to later Europeans nor to Asians. Her genome carries ~3% Neanderthal ancestry, similar to those of other Upper Palaeolithic hunter-gatherers. However, the lengths of the Neanderthal segments are longer than those observed in the currently oldest modern human genome of the ~45,000-year-old Ust’-Ishim individual from Siberia, suggesting that this individual from Zlatý kůň is one of the earliest Eurasian inhabitants following the expansion out of Africa.

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Language(s): eng - English
 Dates: 2021-04-07
 Publication Status: Published online
 Pages: 19
 Publishing info: -
 Table of Contents: Methods
- Laboratory procedures and shotgun sequencing.
- Basic processing and sequence alignment of shotgun data.
- Target enrichment, sequencing and processing.



 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41559-021-01443-x
Other: shh2903
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Title: Nature Ecology & Evolution
  Abbreviation : Nat. Ecol. Evol.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: - Sequence Number: s41559-021-01443-x Start / End Page: - Identifier: ISSN: 2397-334X
CoNE: https://pure.mpg.de/cone/journals/resource/2397-334X