Orientation selectivity and the functional clustering of synaptic inputs in 
primary visual cortex

Wilson, Daniel E; Whitney, David E; Scholl, Benjamin; Fitzpatrick, David

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Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex

Wilson, D. E., Whitney, D. E., Scholl, B., & Fitzpatrick, D. (2016). Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex. Nat Neurosci, 19, 1003-1009. Retrieved from https://doi.org/10.1038/nn.4323.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-D4F2-C Version Permalink: https://hdl.handle.net/21.11116/0000-0004-EC6D-9

Genre: Journal Article

Alternative Title : Nat Neurosci

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Wilson, Daniel E¹, Author
Whitney, David E¹, Author
Scholl, Benjamin¹, Author
Fitzpatrick, David¹, Author

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1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288

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Abstract: The majority of neurons in primary visual cortex are tuned for stimulus orientation, but the factors that account for the range of orientation selectivities exhibited by cortical neurons remain unclear. To address this issue, we used in vivo two-photon calcium imaging to characterize the orientation tuning and spatial arrangement of synaptic inputs to the dendritic spines of individual pyramidal neurons in layer 2/3 of ferret visual cortex. The summed synaptic input to individual neurons reliably predicted the neuron's orientation preference, but did not account for differences in orientation selectivity among neurons. These differences reflected a robust input-output nonlinearity that could not be explained by spike threshold alone and was strongly correlated with the spatial clustering of co-tuned synaptic inputs within the dendritic field. Dendritic branches with more co-tuned synaptic clusters exhibited greater rates of local dendritic calcium events, supporting a prominent role for functional clustering of synaptic inputs in dendritic nonlinearities that shape orientation selectivity.

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Dates: Date issued: 2016

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Identifiers: URI: https://doi.org/10.1038/nn.4323

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Title: Nat Neurosci

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Pages: - Volume / Issue: 19 Sequence Number: - Start / End Page: 1003 - 1009 Identifier: -